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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Letermovir PIS2M1 Letermovir PIS2M1 Letermovir PIS1M1 Letermovir PIS1M1 Letermovir Letermovir Letermovir PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Letermovir undergoes metabolism to give Letermovir PIS1M1, Letermovir PIS1M2 and Letermovir PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Letermovir PIS2M1 Letermovir PIS2M1 Letermovir PIS1M1 Letermovir PIS1M1 Letermovir Letermovir Letermovir PIS1M2 Urinary Excretion and/or Bile duct Excretion