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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Maraviroc PIS2M1 Maraviroc PIS2M1 Maraviroc PIS1M1 Maraviroc PIS1M1 Maraviroc Maraviroc Maraviroc PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Maraviroc undergoes metabolism to give Maraviroc PIS1M1, Maraviroc PIS1M2 and Maraviroc PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Maraviroc PIS2M1 Maraviroc PIS2M1 Maraviroc PIS1M1 Maraviroc PIS1M1 Maraviroc Maraviroc Maraviroc PIS1M2 Urinary Excretion and/or Bile duct Excretion