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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Pipotiazine PIS2M1 Pipotiazine PIS2M1 Pipotiazine PIS1M1 Pipotiazine PIS1M1 Pipotiazine Pipotiazine Pipotiazine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Pipotiazine undergoes metabolism to give Pipotiazine PIS1M1, Pipotiazine PIS1M2 and Pipotiazine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Pipotiazine PIS2M1 Pipotiazine PIS2M1 Pipotiazine PIS1M1 Pipotiazine PIS1M1 Pipotiazine Pipotiazine Pipotiazine PIS1M2 Urinary Excretion and/or Bile duct Excretion