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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Zafirlukast PIS2M1 Zafirlukast PIS2M1 Zafirlukast PIS1M1 Zafirlukast PIS1M1 Zafirlukast Zafirlukast Zafirlukast PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Zafirlukast undergoes metabolism to give Zafirlukast PIS1M1, Zafirlukast PIS1M2 and Zafirlukast PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Zafirlukast PIS2M1 Zafirlukast PIS2M1 Zafirlukast PIS1M1 Zafirlukast PIS1M1 Zafirlukast Zafirlukast Zafirlukast PIS1M2 Urinary Excretion and/or Bile duct Excretion