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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Lovastatin Lovastatin Lovastatin PIS1M1 Lovastatin PIS1M2 Lovastatin PIS1M3 Lovastatin PIS1M3 Lovastatin PIS1M1 Lovastatin PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Lovastatin undergoes metabolism to give Lovastatin PIS1M1, Lovastatin PIS1M2 and Lovastatin PIS1M3.
Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Lovastatin Lovastatin Lovastatin PIS1M1 Lovastatin PIS1M2 Lovastatin PIS1M3 Lovastatin PIS1M3 Lovastatin PIS1M1 Lovastatin PIS1M2 Urinary Excretion and/or Bile duct Excretion