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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Ximelagatran Ximelagatran Ximelagatran PIS1M1 Ximelagatran PIS1M2 Ximelagatran PIS1M3 Ximelagatran PIS1M3 Ximelagatran PIS1M1 Ximelagatran PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ximelagatran undergoes metabolism to give Ximelagatran PIS1M1, Ximelagatran PIS1M2 and Ximelagatran PIS1M3.
Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Ximelagatran Ximelagatran Ximelagatran PIS1M1 Ximelagatran PIS1M2 Ximelagatran PIS1M3 Ximelagatran PIS1M3 Ximelagatran PIS1M1 Ximelagatran PIS1M2 Urinary Excretion and/or Bile duct Excretion