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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Agomelatine Agomelatine Agomelatine PIS1M2 Agomelatine PIS2M1 Agomelatine PIS2M1 Agomelatine PIS1M1 Agomelatine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Agomelatine undergoes metabolism to give Agomelatine PIS1M1, Agomelatine PIS1M2 and Agomelatine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Agomelatine Agomelatine Agomelatine PIS1M2 Agomelatine PIS2M1 Agomelatine PIS2M1 Agomelatine PIS1M1 Agomelatine PIS1M2 Urinary Excretion and/or Bile duct Excretion