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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Ketamine Ketamine Ketamine PIS1M2 Ketamine PIS2M1 Ketamine PIS2M1 Ketamine PIS1M1 Ketamine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ketamine undergoes metabolism to give Ketamine PIS1M1, Ketamine PIS1M2 and Ketamine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Ketamine Ketamine Ketamine PIS1M2 Ketamine PIS2M1 Ketamine PIS2M1 Ketamine PIS1M1 Ketamine PIS1M2 Urinary Excretion and/or Bile duct Excretion