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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Methoxsalen Methoxsalen Methoxsalen PIS1M2 Methoxsalen PIS2M1 Methoxsalen PIS2M1 Methoxsalen PIS1M1 Methoxsalen PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Methoxsalen undergoes metabolism to give Methoxsalen PIS1M1, Methoxsalen PIS1M2 and Methoxsalen PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Methoxsalen Methoxsalen Methoxsalen PIS1M2 Methoxsalen PIS2M1 Methoxsalen PIS2M1 Methoxsalen PIS1M1 Methoxsalen PIS1M2 Urinary Excretion and/or Bile duct Excretion