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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Physostigmine Physostigmine Physostigmine PIS1M2 Physostigmine PIS2M1 Physostigmine PIS2M1 Physostigmine PIS1M1 Physostigmine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Physostigmine undergoes metabolism to give Physostigmine PIS1M1, Physostigmine PIS1M2 and Physostigmine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Physostigmine Physostigmine Physostigmine PIS1M2 Physostigmine PIS2M1 Physostigmine PIS2M1 Physostigmine PIS1M1 Physostigmine PIS1M2 Urinary Excretion and/or Bile duct Excretion