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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Ripretinib Ripretinib Ripretinib PIS1M2 Ripretinib PIS2M1 Ripretinib PIS2M1 Ripretinib PIS1M1 Ripretinib PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ripretinib undergoes metabolism to give Ripretinib PIS1M1, Ripretinib PIS1M2 and Ripretinib PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Ripretinib Ripretinib Ripretinib PIS1M2 Ripretinib PIS2M1 Ripretinib PIS2M1 Ripretinib PIS1M1 Ripretinib PIS1M2 Urinary Excretion and/or Bile duct Excretion