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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sulfadoxine Sulfadoxine Sulfadoxine PIS1M2 Sulfadoxine PIS2M1 Sulfadoxine PIS2M1 Sulfadoxine PIS1M1 Sulfadoxine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sulfadoxine undergoes metabolism to give Sulfadoxine PIS1M1, Sulfadoxine PIS1M2 and Sulfadoxine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Sulfadoxine Sulfadoxine Sulfadoxine PIS1M2 Sulfadoxine PIS2M1 Sulfadoxine PIS2M1 Sulfadoxine PIS1M1 Sulfadoxine PIS1M2 Urinary Excretion and/or Bile duct Excretion