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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sulfamerazine Sulfamerazine Sulfamerazine PIS1M2 Sulfamerazine PIS2M1 Sulfamerazine PIS2M1 Sulfamerazine PIS1M1 Sulfamerazine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sulfamerazine undergoes metabolism to give Sulfamerazine PIS1M1, Sulfamerazine PIS1M2 and Sulfamerazine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Sulfamerazine Sulfamerazine Sulfamerazine PIS1M2 Sulfamerazine PIS2M1 Sulfamerazine PIS2M1 Sulfamerazine PIS1M1 Sulfamerazine PIS1M2 Urinary Excretion and/or Bile duct Excretion