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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sulfamethazine Sulfamethazine Sulfamethazine PIS1M2 Sulfamethazine PIS2M1 Sulfamethazine PIS2M1 Sulfamethazine PIS1M1 Sulfamethazine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sulfamethazine undergoes metabolism to give Sulfamethazine PIS1M1, Sulfamethazine PIS1M2 and Sulfamethazine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Sulfamethazine Sulfamethazine Sulfamethazine PIS1M2 Sulfamethazine PIS2M1 Sulfamethazine PIS2M1 Sulfamethazine PIS1M1 Sulfamethazine PIS1M2 Urinary Excretion and/or Bile duct Excretion