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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Tetrabenazine Tetrabenazine Tetrabenazine PIS1M2 Tetrabenazine PIS2M1 Tetrabenazine PIS2M1 Tetrabenazine PIS1M1 Tetrabenazine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Tetrabenazine undergoes metabolism to give Tetrabenazine PIS1M1, Tetrabenazine PIS1M2 and Tetrabenazine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Tetrabenazine Tetrabenazine Tetrabenazine PIS1M2 Tetrabenazine PIS2M1 Tetrabenazine PIS2M1 Tetrabenazine PIS1M1 Tetrabenazine PIS1M2 Urinary Excretion and/or Bile duct Excretion