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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Tolnaftate Tolnaftate Tolnaftate PIS1M2 Tolnaftate PIS2M1 Tolnaftate PIS2M1 Tolnaftate PIS1M1 Tolnaftate PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Tolnaftate undergoes metabolism to give Tolnaftate PIS1M1, Tolnaftate PIS1M2 and Tolnaftate PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Tolnaftate Tolnaftate Tolnaftate PIS1M2 Tolnaftate PIS2M1 Tolnaftate PIS2M1 Tolnaftate PIS1M1 Tolnaftate PIS1M2 Urinary Excretion and/or Bile duct Excretion