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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Travoprost Travoprost Travoprost PIS1M2 Travoprost PIS2M1 Travoprost PIS2M1 Travoprost PIS1M1 Travoprost PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Travoprost undergoes metabolism to give Travoprost PIS1M1, Travoprost PIS1M2 and Travoprost PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Travoprost Travoprost Travoprost PIS1M2 Travoprost PIS2M1 Travoprost PIS2M1 Travoprost PIS1M1 Travoprost PIS1M2 Urinary Excretion and/or Bile duct Excretion