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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Vardenafil Vardenafil Vardenafil PIS1M2 Vardenafil PIS2M1 Vardenafil PIS2M1 Vardenafil PIS1M1 Vardenafil PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Vardenafil undergoes metabolism to give Vardenafil PIS1M1, Vardenafil PIS1M2 and Vardenafil PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Vardenafil Vardenafil Vardenafil PIS1M2 Vardenafil PIS2M1 Vardenafil PIS2M1 Vardenafil PIS1M1 Vardenafil PIS1M2 Urinary Excretion and/or Bile duct Excretion