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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Vinblastine Vinblastine Vinblastine PIS1M2 Vinblastine PIS2M1 Vinblastine PIS2M1 Vinblastine PIS1M1 Vinblastine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Vinblastine undergoes metabolism to give Vinblastine PIS1M1, Vinblastine PIS1M2 and Vinblastine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Vinblastine Vinblastine Vinblastine PIS1M2 Vinblastine PIS2M1 Vinblastine PIS2M1 Vinblastine PIS1M1 Vinblastine PIS1M2 Urinary Excretion and/or Bile duct Excretion