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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Vinorelbine Vinorelbine Vinorelbine PIS1M2 Vinorelbine PIS2M1 Vinorelbine PIS2M1 Vinorelbine PIS1M1 Vinorelbine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Vinorelbine undergoes metabolism to give Vinorelbine PIS1M1, Vinorelbine PIS1M2 and Vinorelbine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Vinorelbine Vinorelbine Vinorelbine PIS1M2 Vinorelbine PIS2M1 Vinorelbine PIS2M1 Vinorelbine PIS1M1 Vinorelbine PIS1M2 Urinary Excretion and/or Bile duct Excretion