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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Novobiocin Novobiocin PIS4M1 Novobiocin PIS4M1 Novobiocin Novobiocin PIS1M1 Novobiocin PIS2M1 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Kidney Bile Ducts Liver Blood Vessel Blood Vessel Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions. Novobiocin undergoes metabolism to give Novobiocin PIS1M1, Novobiocin PIS2M1 and Novobiocin PIS4M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Novobiocin Novobiocin PIS4M1 Novobiocin PIS4M1 Novobiocin Novobiocin PIS1M1 Novobiocin PIS2M1 Urinary Excretion and/or Bile duct Excretion