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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sulfoxone Sulfoxone PIS4M1 Sulfoxone PIS4M1 Sulfoxone Sulfoxone PIS1M1 Sulfoxone PIS2M1 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Kidney Bile Ducts Liver Blood Vessel Blood Vessel Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions. Sulfoxone undergoes metabolism to give Sulfoxone PIS1M1, Sulfoxone PIS2M1 and Sulfoxone PIS4M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Sulfoxone Sulfoxone PIS4M1 Sulfoxone PIS4M1 Sulfoxone Sulfoxone PIS1M1 Sulfoxone PIS2M1 Urinary Excretion and/or Bile duct Excretion