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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Aclidinium PIS2M1 Aclidinium PIS2M2 Aclidinium Aclidinium Aclidinium PIS1M1 Aclidinium PIS2M1 Aclidinium PIS2M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Aclidinium undergoes metabolism to give Aclidinium PIS1M1, Aclidinium PIS2M1 and Aclidinium PIS4M1. Endoplasmic Reticulum Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Aclidinium PIS2M1 Aclidinium PIS2M2 Aclidinium Aclidinium Aclidinium PIS1M1 Aclidinium PIS2M1 Aclidinium PIS2M2 Urinary Excretion and/or Bile duct Excretion