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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Rapacuronium PIS2M1 Rapacuronium PIS2M2 Rapacuronium Rapacuronium Rapacuronium PIS1M1 Rapacuronium PIS2M1 Rapacuronium PIS2M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Rapacuronium undergoes metabolism to give Rapacuronium PIS1M1, Rapacuronium PIS2M1 and Rapacuronium PIS4M1. Endoplasmic Reticulum Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Rapacuronium PIS2M1 Rapacuronium PIS2M2 Rapacuronium Rapacuronium Rapacuronium PIS1M1 Rapacuronium PIS2M1 Rapacuronium PIS2M2 Urinary Excretion and/or Bile duct Excretion