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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 1A2 Acalabrutinib Acalabrutinib Acalabrutinib PIS1M2 Acalabrutinib PIS2M1 Acalabrutinib PIS2M1 Acalabrutinib PIS1M1 Acalabrutinib PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Acalabrutinib undergoes metabolism to give Acalabrutinib PIS1M1, Acalabrutinib PIS1M2 and Acalabrutinib PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP1A2 CYP1A2 Acalabrutinib Acalabrutinib Acalabrutinib PIS1M2 Acalabrutinib PIS2M1 Acalabrutinib PIS2M1 Acalabrutinib PIS1M1 Acalabrutinib PIS1M2 Urinary Excretion and/or Bile duct Excretion