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Unknown Cytochrome P450 3A4 Cytochrome P450 2D6 Cytochrome P450 1A2 Theophylline PIS2M1 Theophylline PIS2M1 Theophylline PIS1M1 Theophylline PIS1M1 Theophylline Theophylline Theophylline PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Theophylline undergoes metabolism to give Theophylline PIS1M1, Theophylline PIS1M2 and Theophylline PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP2D6 CYP1A2 Theophylline PIS2M1 Theophylline PIS2M1 Theophylline PIS1M1 Theophylline PIS1M1 Theophylline Theophylline Theophylline PIS1M2 Urinary Excretion and/or Bile duct Excretion