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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Trimethoprim Trimethoprim Trimethoprim PIS1M2 Trimethoprim PIS1M3 Trimethoprim PIS1M3 Trimethoprim PIS2M1 Trimethoprim PIS2M1 Trimethoprim PIS1M1 Trimethoprim PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Trimethoprim undergoes metabolism to give Trimethoprim PIS1M1, Trimethoprim PIS1M2, Trimethoprim PIS1M3 and Trimethoprim PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Trimethoprim Trimethoprim Trimethoprim PIS1M2 Trimethoprim PIS1M3 Trimethoprim PIS1M3 Trimethoprim PIS2M1 Trimethoprim PIS2M1 Trimethoprim PIS1M1 Trimethoprim PIS1M2 Urinary Excretion and/or Bile duct Excretion