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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Acebutolol Acebutolol Acebutolol PIS1M2 Acebutolol PIS1M3 Acebutolol PIS1M3 Acebutolol PIS2M1 Acebutolol PIS2M1 Acebutolol PIS1M1 Acebutolol PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Acebutolol undergoes metabolism to give Acebutolol PIS1M1, Acebutolol PIS1M2, Acebutolol PIS1M3 and Acebutolol PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Acebutolol Acebutolol Acebutolol PIS1M2 Acebutolol PIS1M3 Acebutolol PIS1M3 Acebutolol PIS2M1 Acebutolol PIS2M1 Acebutolol PIS1M1 Acebutolol PIS1M2 Urinary Excretion and/or Bile duct Excretion