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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Sildenafil PIS2M1 Sildenafil PIS2M1 Sildenafil PIS1M1 Sildenafil PIS1M1 Sildenafil Sildenafil Pentazocine PIS2M2 Pentazocine PIS2M2 Sildenafil PIS1M2 Pentazocine PIS1M3 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Sildenafil undergoes metabolism to give Sildenafil PIS1M1, Sildenafil PIS1M2, Sildenafil PIS1M3, Sildenafil PIS2M1 and Sildenafil PIS2M2.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP1A2 Sildenafil PIS2M1 Sildenafil PIS2M1 Sildenafil PIS1M1 Sildenafil PIS1M1 Sildenafil Sildenafil Pentazocine PIS2M2 Pentazocine PIS2M2 Sildenafil PIS1M2 Pentazocine PIS1M3 Urinary Excretion and/or Bile duct Excretion