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Unknown Unknown Unknown Unknown Cytochrome P450 1A2 Cytochrome P450 1A2 Cytochrome P450 1A2 Cytochrome P450 3A4 Belumosudil Belumosudil Belumosudil PIS1M2 Belumosudil PIS2M2 Belumosudil PIS2M2 Belumosudil PIS2M1 Belumosudil PIS2M1 Belumosudil PIS1M1 Belumosudil PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Belumosudil undergoes metabolism to give Belumosudil PIS1M1, Belumosudil PIS1M2, Belumosudil PIS1M3 and Belumosudil PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP1A2 CYP1A2 CYP1A2 CYP3A4 Belumosudil Belumosudil Belumosudil PIS1M2 Belumosudil PIS2M2 Belumosudil PIS2M2 Belumosudil PIS2M1 Belumosudil PIS2M1 Belumosudil PIS1M1 Belumosudil PIS1M2 Urinary Excretion and/or Bile duct Excretion