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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Trospium Trospium Pentazocine PIS2M1 Pentazocine PIS2M1 Midodrine PIS1M1 Midodrine PIS1M1 Midodrine Midodrine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sildenafil undergoes metabolism to give Sildenafil PIS1M1, Sildenafil PIS2M1 and Sildenafil PIS4M1. Endoplasmic Reticulum Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Trospium Trospium Pentazocine PIS2M1 Pentazocine PIS2M1 Midodrine PIS1M1 Midodrine PIS1M1 Midodrine Midodrine PIS1M2 Urinary Excretion and/or Bile duct Excretion