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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Isosulfan blue Isosulfan blue Isosulfan blue PIS4M1 Isosulfan blue PIS4M1 Isosulfan blue PIS2M1 Isosulfan blue PIS2M1 Isosulfan blue PIS1M1 Isosulfan blue PIS2M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Isosulfan blue undergoes metabolism to give Isosulfan blue PIS1M1, Isosulfan blue PIS2M1 and Isosulfan blue PIS4M1. Endoplasmic Reticulum Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Isosulfan blue Isosulfan blue Isosulfan blue PIS4M1 Isosulfan blue PIS4M1 Isosulfan blue PIS2M1 Isosulfan blue PIS2M1 Isosulfan blue PIS1M1 Isosulfan blue PIS2M2 Urinary Excretion and/or Bile duct Excretion