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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Isometheptene Isometheptene Isometheptene PIS1M2 Isometheptene PIS1M3 Isometheptene PIS1M3 Isometheptene PIS1M1 Isometheptene PIS1M1 Isometheptene PIS1M4 Isometheptene PIS1M4 Isometheptene PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Isometheptene undergoes metabolism to give Isometheptene PIS1M1, Isometheptene PIS1M2, Isometheptene PIS1M3 and Isometheptene PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Isometheptene Isometheptene Isometheptene PIS1M2 Isometheptene PIS1M3 Isometheptene PIS1M3 Isometheptene PIS1M1 Isometheptene PIS1M1 Isometheptene PIS1M4 Isometheptene PIS1M4 Isometheptene PIS1M2 Urinary Excretion and/or Bile duct Excretion