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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Malathion Malathion Malathion PIS2M1 Malathion PIS2M1 Malathion PIS4M1 Malathion PIS4M1 Malathion PIS1M2 Malathion PIS2M2 Malathion PIS1M1 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Malathion undergoes metabolism to give Malathion PIS1M1, Malathion PIS1M2, Malathion PIS1M3, Malathion PIS1M4 and Malathion PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Malathion Malathion Malathion PIS2M1 Malathion PIS2M1 Malathion PIS4M1 Malathion PIS4M1 Malathion PIS1M2 Malathion PIS2M2 Malathion PIS1M1 Urinary Excretion and/or Bile duct Excretion