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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sulfamethoxazole Sulfamethoxazole Sulfamethoxazole PIIS2M1 Sulfamethoxazole PIIS2M1 Sulfamethoxazole PIIS4M1 Sulfamethoxazole PIIS4M1 Sulfamethoxazole PIS1M2 Sulfamethoxazole PIS2M1 Sulfamethoxazole PIS1M1 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sulfamethoxazole undergoes metabolism to give Sulfamethoxazole PIS1M1, Sulfamethoxazole PIS1M2, Sulfamethoxazole PIS1M3, Sulfamethoxazole PIS1M4 and Sulfamethoxazole PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Sulfamethoxazole Sulfamethoxazole Sulfamethoxazole PIIS2M1 Sulfamethoxazole PIIS2M1 Sulfamethoxazole PIIS4M1 Sulfamethoxazole PIIS4M1 Sulfamethoxazole PIS1M2 Sulfamethoxazole PIS2M1 Sulfamethoxazole PIS1M1 Urinary Excretion and/or Bile duct Excretion