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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Rebamipide Rebamipide Rebamipide PIS2M2 Rebamipide PIS2M2 Rebamipide PIS1M1 Rebamipide PIS1M1 Rebamipide PIS2M1 Rebamipide PIS2M1 Rebamipide PIS1M2 Rebamipide PIS1M3 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Rebamipide undergoes metabolism to give Rebamipide PIS1M1, Rebamipide PIS1M2, Rebamipide PIS1M3, Rebamipide PIS1M4 and Rebamipide PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Rebamipide Rebamipide Rebamipide PIS2M2 Rebamipide PIS2M2 Rebamipide PIS1M1 Rebamipide PIS1M1 Rebamipide PIS2M1 Rebamipide PIS2M1 Rebamipide PIS1M2 Rebamipide PIS1M3 Urinary Excretion and/or Bile duct Excretion