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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Torasemide Torasemide Torasemide PIS2M1 Torasemide PIS2M1 Torasemide PIS1M2 Torasemide PIS1M2 Torasemide PIS2M2 Torasemide PIS2M2 Torasemide PIS1M1 Torasemide PIS1M3 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Torasemide undergoes metabolism to give Torasemide PIS1M1, Torasemide PIS1M2, Torasemide PIS1M3, Torasemide PIS1M4 and Torasemide PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Torasemide Torasemide Torasemide PIS2M1 Torasemide PIS2M1 Torasemide PIS1M2 Torasemide PIS1M2 Torasemide PIS2M2 Torasemide PIS2M2 Torasemide PIS1M1 Torasemide PIS1M3 Urinary Excretion and/or Bile duct Excretion