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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Thalidomide Thalidomide Thalidomide PIS1M2 Thalidomide PIS2M2 Thalidomide PIS2M2 Thalidomide PIS2M1 Thalidomide PIS2M1 Thalidomide PIS1M3 Thalidomide PIS1M3 Thalidomide PIS1M1 Thalidomide PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Thalidomide undergoes metabolism to give Thalidomide PIS1M1, Thalidomide PIS1M2, Thalidomide PIS1M3, Thalidomide PIS1M4 and Thalidomide PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP1A2 CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 Thalidomide Thalidomide Thalidomide PIS1M2 Thalidomide PIS2M2 Thalidomide PIS2M2 Thalidomide PIS2M1 Thalidomide PIS2M1 Thalidomide PIS1M3 Thalidomide PIS1M3 Thalidomide PIS1M1 Thalidomide PIS1M2 Urinary Excretion and/or Bile duct Excretion