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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Ticagrelor Ticagrelor Ticagrelor PIS1M2 Ticagrelor PIS2M2 Ticagrelor PIS2M2 Ticagrelor PIS2M1 Ticagrelor PIS2M1 Ticagrelor PIS1M3 Ticagrelor PIS1M3 Ticagrelor PIS1M1 Ticagrelor PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ticagrelor undergoes metabolism to give Ticagrelor PIS1M1, Ticagrelor PIS1M2, Ticagrelor PIS1M3, Ticagrelor PIS1M4 and Ticagrelor PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP1A2 CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 Ticagrelor Ticagrelor Ticagrelor PIS1M2 Ticagrelor PIS2M2 Ticagrelor PIS2M2 Ticagrelor PIS2M1 Ticagrelor PIS2M1 Ticagrelor PIS1M3 Ticagrelor PIS1M3 Ticagrelor PIS1M1 Ticagrelor PIS1M2 Urinary Excretion and/or Bile duct Excretion