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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Troglitazone Troglitazone Troglitazone PIS1M4 Troglitazone PIS1M2 Troglitazone PIS1M2 Troglitazone PIS1M3 Troglitazone PIS1M3 Troglitazone PIS2M1 Troglitazone PIS2M1 Troglitazone PIS1M1 Troglitazone PIS1M4 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Troglitazone undergoes metabolism to give Troglitazone PIS1M1, Troglitazone PIS1M2, Troglitazone PIS1M3, Troglitazone PIS1M4 and Troglitazone PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Troglitazone Troglitazone Troglitazone PIS1M4 Troglitazone PIS1M2 Troglitazone PIS1M2 Troglitazone PIS1M3 Troglitazone PIS1M3 Troglitazone PIS2M1 Troglitazone PIS2M1 Troglitazone PIS1M1 Troglitazone PIS1M4 Urinary Excretion and/or Bile duct Excretion