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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Midodrine Midodrine Midodrine PIS1M2 Esmolol PIS1M3 Esmolol PIS1M3 Midodrine PIS2M1 Midodrine PIS2M1 Pentazocine PIS2M2 Pentazocine PIS2M2 Midodrine PIS1M1 Midodrine PIS1M2 Pentazocine PIS1M3 Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sildenafil undergoes metabolism to give Sildenafil PIS1M1, Sildenafil PIS1M2, Sildenafil PIS1M3, Sildenafil PIS1M4, Sildenafil PIS1M5 and Sildenafil PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Midodrine Midodrine Midodrine PIS1M2 Esmolol PIS1M3 Esmolol PIS1M3 Midodrine PIS2M1 Midodrine PIS2M1 Pentazocine PIS2M2 Pentazocine PIS2M2 Midodrine PIS1M1 Midodrine PIS1M2 Pentazocine PIS1M3 Urinary Excretion and/or Bile duct Excretion