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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Loxapine Loxapine Loxapine PIS1M1 Loxapine PIIS1M1 Loxapine PIIS1M1 Loxapine PIS2M1 Loxapine PIS2M1 Loxapine PIS2M2 Loxapine PIS2M2 Loxapine PIS1M1 Loxapine PIS1M1 Loxapine PIS1M2 Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Loxapine undergoes metabolism to give Loxapine PIS1M1, Loxapine PIS1M2, Loxapine PIS1M3, Loxapine PIS1M4, Loxapine PIS1M5 and Loxapine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Loxapine Loxapine Loxapine PIS1M1 Loxapine PIIS1M1 Loxapine PIIS1M1 Loxapine PIS2M1 Loxapine PIS2M1 Loxapine PIS2M2 Loxapine PIS2M2 Loxapine PIS1M1 Loxapine PIS1M1 Loxapine PIS1M2 Urinary Excretion and/or Bile duct Excretion