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Unknown Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Ketoconazole Ketoconazole Ketoconazole PIS1M3 Ketoconazole PIS2M2 Ketoconazole PIS2M2 Ketoconazole PIS2M3 Ketoconazole PIS2M3 Ketoconazole PIS1M2 Ketoconazole PIS1M2 Ketoconazole PIS2M1 Ketoconazole PIS2M1 Ketoconazole PIS1M1 Ketoconazole PIS1M3 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ketoconazole undergoes metabolism to give Ketoconazole PIS1M1, Ketoconazole PIS1M2, Ketoconazole PIS1M3, Ketoconazole PIS1M4, Ketoconazole PIS1M5 and Ketoconazole PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 CYP1A2 Ketoconazole Ketoconazole Ketoconazole PIS1M3 Ketoconazole PIS2M2 Ketoconazole PIS2M2 Ketoconazole PIS2M3 Ketoconazole PIS2M3 Ketoconazole PIS1M2 Ketoconazole PIS1M2 Ketoconazole PIS2M1 Ketoconazole PIS2M1 Ketoconazole PIS1M1 Ketoconazole PIS1M3 Urinary Excretion and/or Bile duct Excretion