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Unknown Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Ponesimod Ponesimod Ponesimod PIS1M3 Ponesimod PIS2M2 Ponesimod PIS2M2 Ponesimod PIS2M3 Ponesimod PIS2M3 Ponesimod PIS1M2 Ponesimod PIS1M2 Ponesimod PIS2M1 Ponesimod PIS2M1 Ponesimod PIS1M1 Ponesimod PIS1M3 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ponesimod undergoes metabolism to give Ponesimod PIS1M1, Ponesimod PIS1M2, Ponesimod PIS1M3, Ponesimod PIS1M4, Ponesimod PIS1M5 and Ponesimod PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 CYP1A2 Ponesimod Ponesimod Ponesimod PIS1M3 Ponesimod PIS2M2 Ponesimod PIS2M2 Ponesimod PIS2M3 Ponesimod PIS2M3 Ponesimod PIS1M2 Ponesimod PIS1M2 Ponesimod PIS2M1 Ponesimod PIS2M1 Ponesimod PIS1M1 Ponesimod PIS1M3 Urinary Excretion and/or Bile duct Excretion