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Unknown Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Tazemetostat Tazemetostat Tazemetostat PIS1M3 Tazemetostat PIS2M2 Tazemetostat PIS2M2 Tazemetostat PIS4M1 Tazemetostat PIS4M1 Tazemetostat PIS1M2 Tazemetostat PIS1M2 Tazemetostat PIS2M1 Tazemetostat PIS2M1 Tazemetostat PIS1M1 Tazemetostat PIS1M3 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Tazemetostat undergoes metabolism to give Tazemetostat PIS1M1, Tazemetostat PIS1M2, Tazemetostat PIS1M3, Tazemetostat PIS1M4, Tazemetostat PIS1M5 and Tazemetostat PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 CYP1A2 Tazemetostat Tazemetostat Tazemetostat PIS1M3 Tazemetostat PIS2M2 Tazemetostat PIS2M2 Tazemetostat PIS4M1 Tazemetostat PIS4M1 Tazemetostat PIS1M2 Tazemetostat PIS1M2 Tazemetostat PIS2M1 Tazemetostat PIS2M1 Tazemetostat PIS1M1 Tazemetostat PIS1M3 Urinary Excretion and/or Bile duct Excretion