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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Atosiban Atosiban Atosiban PIS1M3 Atosiban PIS2M1 Atosiban PIS2M1 Atosiban PIS2M2 Atosiban PIS2M2 Atosiban PIS2M3 Atosiban PIS2M3 Atosiban PIS1M1 Atosiban PIS1M3 Atosiban PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Atosiban undergoes metabolism to give Atosiban PIS1M1, Atosiban PIS1M2, Atosiban PIS1M3, Atosiban PIS1M4, Atosiban PIS1M5 and Atosiban PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 CYP1A2 CYP3A4 Atosiban Atosiban Atosiban PIS1M3 Atosiban PIS2M1 Atosiban PIS2M1 Atosiban PIS2M2 Atosiban PIS2M2 Atosiban PIS2M3 Atosiban PIS2M3 Atosiban PIS1M1 Atosiban PIS1M3 Atosiban PIS1M2 Urinary Excretion and/or Bile duct Excretion