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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Benzethonium Benzethonium Benzethonium PIS1M3 Benzethonium PIS2M3 Benzethonium PIS2M3 Benzethonium PIS2M2 Benzethonium PIS2M2 Benzethonium PIS2M1 Benzethonium PIS2M1 Benzethonium PIS1M1 Benzethonium PIS1M3 Benzethonium PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Benzethonium undergoes metabolism to give Benzethonium PIS1M1, Benzethonium PIS1M2, Benzethonium PIS1M3, Benzethonium PIS1M4, Benzethonium PIS1M5 and Benzethonium PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 CYP1A2 CYP3A4 Benzethonium Benzethonium Benzethonium PIS1M3 Benzethonium PIS2M3 Benzethonium PIS2M3 Benzethonium PIS2M2 Benzethonium PIS2M2 Benzethonium PIS2M1 Benzethonium PIS2M1 Benzethonium PIS1M1 Benzethonium PIS1M3 Benzethonium PIS1M2 Urinary Excretion and/or Bile duct Excretion