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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Tocainide Tocainide Midodrine PIS2M1 Midodrine PIS2M1 Tocainide PIS2M1 Tocainide PIS2M1 Tocainide PIS1M4 Tocainide PIS1M4 Tocainide PIS2M2 Tocainide PIS2M2 Tocainide PIS1M1 Tocainide PIS1M3 Tocainide PIS1M2 Heme Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Tocainide undergoes metabolism to give Tocainide PIS1M1, Tocainide PIS1M2, Tocainide PIS1M3, Tocainide PIS1M4, Tocainide PIS1M5, Tocainide PIS1M6 and Tocainide PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Tocainide Tocainide Midodrine PIS2M1 Midodrine PIS2M1 Tocainide PIS2M1 Tocainide PIS2M1 Tocainide PIS1M4 Tocainide PIS1M4 Tocainide PIS2M2 Tocainide PIS2M2 Tocainide PIS1M1 Tocainide PIS1M3 Tocainide PIS1M2 Urinary Excretion and/or Bile duct Excretion