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Anthranilate synthase component 1 Anthranilate--CoA ligase Anthraniloyl-CoA anthraniloyltransferase Anthraniloyl-CoA anthraniloyltransferase 2- aminobenzoylacetyl- CoA thioesterase 2-heptyl-4(1H)- quinolone synthase subunit PqsB 2-heptyl-4(1H)- quinolone synthase subunit PqsB 2-heptyl-3- hydroxy-4(1H)- quinolone synthase Chorismate NH3 Anthranilate Pyruvic acid H2O CoA ATP AMP diphosphate Anthraniloyl-CoA CoA Malonyl-CoA 2- Aminobenzoylacetyl- CoA CO2 H2O 2- Aminobenzoylacetate CoA 1-(2- Aminophenyl)decane- 1,3-dione CO2 2-Heptyl-4(1H)- quinolone H2O NADH H+ O2 2-Heptyl-3- hydroxy- quinolone NAD H2O Mg2+ L-Cysteinyl- protein S- Anthraniloyl- L-cysteinyl- protein S- Anthraniloyl- L-cysteinyl- protein S-Octanoyl-L- cysteinyl- protein L-Cysteinyl- protein TCA Cycle Plasmid Outer Membrane Inner Membrane Periplasm Gram-Negative cell Cytoplasm
trpE pqsA pqsD pqsD pqsE pqsB pqsB pqsH Chorismate Ammonia Anthranilate Pyruvic acid Water Coenzyme A Adenosine triphosphate Adenosine monophosphate diphosphate Anthraniloyl-CoA Coenzyme A Malonyl-CoA 2- Aminobenzoylacetyl- CoA Carbon dioxide Water 2- Aminobenzoylacetate Coenzyme A 1-(2- Aminophenyl)decane- 1,3-dione Carbon dioxide 2-Heptyl-4(1H)- quinolone Water NADH Hydrogen Ion Oxygen 2-Heptyl-3- hydroxy- quinolone NAD Water L-Cysteinyl- protein S-Anthraniloyl- L-cysteinyl- protein S-Anthraniloyl- L-cysteinyl- protein S-Octanoyl-L- cysteinyl- protein L-Cysteinyl- protein TCA Cycle
trpE pqsA pqsD pqsD pqsE pqsB pqsB pqsH Chorism NH3 Anthr Pyr H2O CoA ATP AMP PP2 Ant-CoA CoA MalyCoA DHQ CO2 H2O 2-Amino CoA 1-2-A-1 CO2 HHQ H2O NADH H+ O2 PQS NAD H2O Mg2+ L-Cy-pr S-A-L- S-A-L- S-O-L-c L-Cy-pr PW122577 Plasmid Outer Membrane Inner Membrane Periplasm Gram-Negative cell Cytoplasm
trpE pqsA pqsD pqsD pqsE pqsB pqsB pqsH Chorism NH3 Anthr Pyr H2O CoA ATP AMP PP2 Ant-CoA CoA MalyCoA DHQ CO2 H2O 2-Amino CoA 1-2-A-1 CO2 HHQ H2O NADH H+ O2 PQS NAD H2O L-Cy-pr S-A-L- S-A-L- S-O-L-c L-Cy-pr PW122577