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Pathway Description
Biphenyl degradation
Pseudoxanthomonas spadix
Metabolic Pathway
Biphenyl degradation in Pseudoxanthomonas spadix is a source of carbon and energy. Being hydrophobic biphenyl uptake in Pseudoxanthomonas spadix occurs via diffusion or through specific transport proteins or porins that facilitate passage of aromatic hydrocarbons. The process begins with the initial oxidation of biphenyl by biphenyl 2,3-dioxygenase, to formcis-2,3-Dihydro-2,3-dihydroxybiphenyl. Subsequent oxidation, reductions and hydrolysis result in the formation of 2-Oxopent-4-enoate, a precursor to the citrate cycle.
References
Biphenyl degradation References
Oliveira, J. and Reygaert, W.C., 2019. Gram negative bacteria.
Kanehisa, M., 2002, November. The KEGG database. In ‘In silico’simulation of biological processes: Novartis Foundation Symposium 247 (Vol. 247, pp. 91-103). Chichester, UK: John Wiley & Sons, Ltd.
UniProt Consortium, 2019. UniProt: a worldwide hub of protein knowledge. Nucleic acids research, 47(D1), pp.D506-D515.
Kim, S., Thiessen, P.A., Bolton, E.E., Chen, J., Fu, G., Gindulyte, A., Han, L., He, J., He, S., Shoemaker, B.A. and Wang, J., 2016. PubChem substance and compound databases. Nucleic acids research, 44(D1), pp.D1202-D1213.
de Matos, P., Adams, N., Hastings, J., Moreno, P. and Steinbeck, C., 2012. A database for chemical proteomics: ChEBI. Chemical Proteomics: Methods and Protocols, pp.273-296.
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